I LOVE Who Framed Roger Rabbit? and have been a huge fan ever since I was nine years old. The movie was a big step in animation history and personally, I feel it should remain a standalone film because once sequels come along, it just sort of takes away from the original.
I would be more for animated shorts like featured in the beginning of Honey I Shrunk the Kids and other Disney films, little special nods that keep the characters in the spotlight without making a mess of things.
Sure, I'd go check out a sequel...I'd be first in line but I'd be extremely skeptical. However, no matter how well the movie does, maybe it will mean Roger Rabbit will appear in parks once again and cool merchandise could come into play. While the movie may not be my idea of the greatest thing ever...good things could come out of it.