Spiderman 4 will be a re-tooling of the series. So no Sam Rami as director and Tobey Mcguire as Peter Parker.
From Deadline Hollywood:
Any thoughts on this Micechat kids?Mike Fleming and Nikki Finke have just confirmed that Sony Pictures decided today to reboot the Spider-Man franchise after franchise director Sam Raimi pulled out of Spider-Man 4 because he felt he couldn't make its summer release date and keep the film's creative integrity. This means that Raimi and the cast including star Tobey Maguire are out. There will be no Spider-Man 4. Instead, Mike Fleming is told, the studio will focus on a Summer 2012 reboot from a script by Jamie Vanderbilt with a new director and a new cast.