Here's a few quick tips and tricks for Vista:
Instant Elevation - If you need to run something from the Start menu search bar elevated, instead of pressing Enter, press Ctrl+Shift+Enter. You'll get the UAC prompt, and be good to go.
Turning Hibernation On/Off - If you use Disk Cleanup to delete the Hibernation file, you will find that hibernation/hybrid sleep has been disabled. The only way you can re-enable it is through this command: powercfg -h on, just type that in the Start Search box, and press Ctrl+Shift+Enter. If you ever wish to turn it off, do the same, but use the command powercfg -h off.
Enabling Hybrid Sleep - If you like hibernation, but the quickness of sleep, Vista has a new option for laptops called Hybrid Sleep. To enable it, just head into Power Options in the Control Panel. Then click 'Change Plan Settings' under the selected plan, and then 'Change Advanced Power Settings'. Scroll to 'Sleep', and then 'Hybrid Sleep'.
Changing the Start Menu power button - Hate the fact that the power button defaults to Sleep, instead of Shut Down? To change it, just head into Power Options in the Control Panel. Then click 'Change Plan Settings' under the selected plan, and then 'Change Advanced Power Settings'. Scroll to 'Power Buttons and Lid' > 'Start menu power button'. Then click it to change it from Sleep to Hibernate or Shutdown.
Flip 3D on a mouse button - If you've got one of those fancy mouses that has more than 3 buttons, you can assign Flip 3d to a button. Just assign the command using the latest Razor, Logitech or Microsoft mouse software. Personally, I have it binded to one of the G-keys on my G15 keyboard. Keeps it handy!
Snipping Tool - One of my favorite new Vista features is the Snipping Tool. Found in Start > All Programs > Accessories, the Snipping Tool is like the PrtScr button on steriods. You can pick a window to make an image of for handy screenshots. You can also do the whole screen, or just an area. Save it as a image file, and your ready to upload.
Mass Editing Tags in Photo Gallery - If you wish to mass edit tags on pictures in Windows Photo Gallery, just select multiple pictures, and you can Right-Click for properties, and add your tags.